9H-Carbazole-1-carboxamide, 7-(1-hydroxy-1-methylethyl)-4-[2-methyl-3-(4-oxo-3(4H)-quinazolinyl)phenyl]-

Name	BMS-935177
Synonyms	BMS-935177 1231889-53-4 7-(2-Hydroxypropan-2-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-9H-carbazole-1-carboxamide 9H-Carbazole-1-carboxamide, 7-(1-hydroxy-1-methylethyl)-4-[2-methyl-3-(4-oxo-3(4H)-quinazolinyl)phenyl]-
CAS	1231889-53-4

Molecular Formula	C31H26N4O3
Molar Mass	502.56
Storage Condition	Room Temprature
In vitro study	BMS-935177 the selectivity of BTK is more than 50 times higher than that of SRC kinase family members. In Ramos B cells, BMS-935177 inhibited calcium flux; In peripheral blood B lymphocytes stimulated by anti-IgM and anti-IgG, BMS-935177 inhibited cell surface expression of cd69. However, BMS-935177 of B cells stimulated by CD40 receptor and ligand had no effect on CD69 expression. In PBMCs, BMS-935177 can effectively inhibit the production of TNF-α, IC50 is 14 nM.
In vivo study	The plasma protein binding rate was high in BMS-935177 of the tested species, and the free drug ratio was less than 1% in humans. In preclinical testing, BMS-935177 had good oral activity, whether administered in suspension or in solution, despite its poor water solubility. Administered as a solution, the oral bioavailability in rats, mice, dogs, and cynomolgus monkeys was 84%-100% BMS-935177, while in single intravenous administration experiments, has a low clearance rate in vivo. At a dose of 2 mg/kg I. V. In mice and rats, T BMS-935177 was 4 h and 5.1 h, respectively.

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Product Name: BMS-935177 Visit Supplier Webpage Request for quotation
CAS: 1231889-53-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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9H-Carbazole-1-carboxamide, 7-(1-hydroxy-1-methylethyl)-4-[2-methyl-3-(4-oxo-3(4H)-quinazolinyl)phenyl]- Request for Quotation